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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN2
All Species:
48.79
Human Site:
Y629
Identified Species:
76.67
UniProt:
Q9H0D6
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0D6
NP_036387.2
950
108582
Y629
D
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Chimpanzee
Pan troglodytes
XP_514546
950
108522
Y629
D
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Rhesus Macaque
Macaca mulatta
XP_001094734
961
109718
Y640
D
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Dog
Lupus familis
XP_534324
950
108331
Y629
D
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBR1
951
108669
Y629
D
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Rat
Rattus norvegicus
NP_001102066
561
63850
V293
R
N
S
L
G
S
D
V
L
F
V
G
K
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505862
950
108030
Y629
E
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Chicken
Gallus gallus
Q5ZIP4
949
108524
Y628
E
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM71
908
103942
Y608
E
S
P
I
I
D
F
Y
P
E
D
F
K
I
D
Honey Bee
Apis mellifera
XP_392371
860
99367
L584
D
F
I
N
I
G
G
L
S
T
E
F
E
K
G
Nematode Worm
Caenorhab. elegans
Q9U299
975
110109
Y655
D
S
P
I
I
D
L
Y
P
A
D
F
R
I
D
Sea Urchin
Strong. purpuratus
XP_795068
1073
120270
Y618
D
S
P
I
I
D
L
Y
P
D
D
F
Q
I
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FQ03
1020
116807
Y652
N
S
P
I
I
D
F
Y
P
T
D
F
E
V
D
Baker's Yeast
Sacchar. cerevisiae
Q02792
1006
115915
Y717
D
S
E
I
I
D
F
Y
P
E
E
F
P
I
D
Red Bread Mold
Neurospora crassa
Q8WZX5
1072
118291
Y699
T
S
E
I
R
H
F
Y
P
D
D
F
E
I
D
Conservation
Percent
Protein Identity:
100
99.7
97.6
98
N.A.
96
56.2
N.A.
91.1
82.9
N.A.
N.A.
N.A.
51.2
54
50.5
52.5
Protein Similarity:
100
99.8
98
99
N.A.
97
57.6
N.A.
95.4
90.5
N.A.
N.A.
N.A.
63.2
66.5
63.7
63.4
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
93.3
93.3
N.A.
N.A.
N.A.
80
20
73.3
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
100
100
N.A.
N.A.
N.A.
86.6
26.6
73.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.6
40.5
40.8
Protein Similarity:
N.A.
N.A.
N.A.
58
57.4
56.1
P-Site Identity:
N.A.
N.A.
N.A.
66.6
80
60
P-Site Similarity:
N.A.
N.A.
N.A.
80
86.6
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
0
0
47
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
60
0
0
0
0
80
7
0
0
14
80
0
0
0
87
% D
% Glu:
20
0
14
0
0
0
0
0
0
60
14
0
20
0
0
% E
% Phe:
0
7
0
0
0
0
74
0
0
7
0
94
0
0
0
% F
% Gly:
0
0
0
0
7
7
7
0
0
0
0
7
0
0
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
7
87
87
0
0
0
0
0
0
0
0
80
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
14
7
0
% K
% Leu:
0
0
0
7
0
0
14
7
7
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
27
0
0
0
0
0
87
0
0
0
7
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
7
0
0
0
7
0
0
0
0
0
0
0
7
0
0
% R
% Ser:
0
87
54
0
0
7
0
0
7
0
0
0
0
0
0
% S
% Thr:
7
0
0
0
0
0
0
0
0
14
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
7
0
0
7
0
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
87
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _